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Keep track of Intently (1)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is often a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for achievable dosage changes.Reserve concomitant prescribing of such drugs in sufferers for whom